Tonight there is a meeting of the NYCDOTNET UG at Microsoft's NYC office.
Smart Client Deployment with ClickOnce in .NET 2.0
Brian Noyes, principal software architect, IDesign, Inc.
ClickOnce is a new deployment technology being introduced in .NET 2.0 that provides a trustworthy mechanism for deploying smart client applications over the web or a network with a single deployment to a server.